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NON-OPIOID EXPAREL REDUCES THE NEED FOR OPIOIDS.

Just what makes EXPAREL different?

EXPAREL is targeted, working directly at the surgical site, unlike opioids, which are systemic and affect the entire body
EXPAREL requires only one dose, administered by a doctor during surgery, so you and your family have one less thing to manage afterwards
EXPAREL provides pain control for the first few days after surgery, when patients need it most
EXPAREL is proven in clinical trials to reduce the need for opioids in both adults and children^*
- EXPAREL patients went longer before needing opioids than those who didn’t receive EXPAREL
- EXPAREL patients required fewer opioids than those who didn’t receive EXPAREL

^*The clinical benefit of the decrease in opioid consumption was not demonstrated in the pivotal trials.

EXPAREL has been used in over 10 million patients

Possible side effects

Side effects can occur with any medication. It is important not to ignore anything you may be experiencing. Patients in clinical trials who received EXPAREL and placebo experienced nausea, vomiting, fever, and/or constipation. Speak with your doctor right away if you experience any of these or if you have other questions regarding any side effects.

Learn about your surgery

Select from the surgical procedure list below to learn more about how EXPAREL can help.

GENERAL

Procedures:

Bariatric, Colon, Hemorrhoid, Hernia, Kidney, Stomach

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Oral and Maxillofacial

Procedures:

Implants, TMJ, Wisdom Teeth Extraction

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ORTHOPEDIC

Procedures:

Ankle, Foot, Hand, Hip, Knee, Shoulder, Spine

PEDIATRIC

Procedures:

ACL, Scoliosis/Spine, Tonsillectomy, Wisdom Teeth

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women’s health

Procedures:

Breast, Cesarean Delivery (C-Section), Fibroid, Hysterectomy

PLASTIC SURGERY

Procedures:

Abdominoplasty, Mammoplasty, Breast Reconstruction

Don't see your surgery here? EXPAREL may still be an option. Talk to your doctor to learn more.

Check the frequently asked questions (FAQs) about EXPAREL for more information

If you are interested in EXPAREL FOR YOURSELF OR YOUR CHILD, make sure to talk about your pain Management plan with your doctor before surgery.

FIND A DOCTOR WHO USES EXPAREL

If you are planning for surgery and think EXPAREL is right for you, find doctors and facilities that offer EXPAREL.

Indication

EXPAREL^® (bupivacaine liposome injectable suspension) is indicated to produce postsurgical local analgesia via infiltration in patients aged 6 years and older and regional analgesia in adults via an interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and an adductor canal block. Safety and efficacy have not been established in other nerve blocks.

Important Safety Information

EXPAREL should not be used in obstetrical paracervical block anesthesia.

In studies in adults where EXPAREL was injected into a wound, the most common side effects were nausea, constipation, and vomiting.

In studies in adults where EXPAREL was injected near a nerve, the most common side effects were nausea, fever, headache, and constipation.

In the study where EXPAREL was given to children, the most common side effects were nausea, vomiting, constipation, low blood pressure, low number of red blood cells, muscle twitching, blurred vision, itching, and rapid heartbeat.

EXPAREL can cause a temporary loss of feeling and/or loss of muscle movement. How much and how long the loss of feeling and/or muscle movement depends on where and how much of EXPAREL was injected and may last for up to 5 days.

EXPAREL is not recommended to be used in patients younger than 6 years old for injection into the wound, for patients younger than 18 years old for injection near a nerve, and/or in pregnant women.

Tell your health care provider if you or your child has liver disease, since this may affect how the active ingredient (bupivacaine) in EXPAREL is eliminated from the body.

EXPAREL should not be injected into the spine, joints, or veins.

The active ingredient in EXPAREL can affect the nervous system and the cardiovascular system; may cause an allergic reaction; may cause damage if injected into the joints; and can cause a rare blood disorder.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Important Safety Information